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Understanding Lymphoma


Lymphoma

Lymphoma is the name for a group of blood cancers that develop in the lymphatic system. The two main types are Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL).

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Hodgkin Lymphoma (HL)

  • Is a cancer that affects the lymphatic system, which is part of the body's immune system

  • Is one of the most curable forms of cancer

  • Is named for Dr. Thomas Hodgkin who, in 1832, described several cases of people with symptoms of a cancer involving the lymph nodes. The disease was called "Hodgkin's disease" until it was officially renamed "Hodgkin lymphoma" in the late 20th century.

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Non-Hodgkin Lymphoma (NHL)

  • Is a type of cancer that affects the lymphatic system

  • Generally develops in the lymph nodes and lymphatic tissues. In some cases, NHL involves bone marrow and blood.

  • Isn't just one disease–it's actually a diverse group of blood cancers that share a single characteristic in how they develop.

  •  NHL has many different subtypes, which are either indolent (slow growing) or aggressive (fast growing).


Symptoms and Treatment

Symptoms of Lymphoma

Lymphoma can cause many different signs and symptoms, depending on the type of lymphoma (Hodgkin and Non-Hodgkin are most common), and where it is in the body. Sometimes no symptoms are noticeable until it grows quite large. Some common signs and symptoms include:

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  • Swollen Lymph Nodes in the Neck, Underarms, or Groin

  • Intermittent Fevers

  • Drenching Night Sweats

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  • Feeling Tired All the Time

  • Unexplained Weight Loss

  • Decreased Appetite

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  • Generalized Itching

  • Abdominal Pain or Swelling, Feeling of Fullness

  • Coughing, Shortness of Breath, Chest Discomfort


Lymphoma Treatments Options

Depending on the type and stage of the lymphoma and other factors, treatment options for people with lymphoma can include:

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  • Chemotherapy

  • Radiation Therapy

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  • Immunotherapy

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  • High-Dose Chemotherapy and Stem Cell Transplant

Some Common Subtypes of Non-Hodgkin Lymphoma

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Aggressive

  • Diffuse Large B-Cell Lymphoma (DLBCL)

  • Anaplastic Large Cell Lymphoma

  • Burkitt Lymphoma

  • Lymphoblastic Lymphoma

  • Mantle Cell Lymphoma

  • Peripheral T-Cell Lymphoma

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Indolent

  • Follicular Lymphoma

  • Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sézary Syndrome)

  • Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia

  • Marginal Zone B-Cell Lymphoma

  • MALT Lymphoma

  • Small Cell Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia (SLL/CLL)


Lymphoma Fast Facts

New Cases

 

  • In 2025, there are expected to be 89,070 new cases of lymphoma diagnosed in the US (8,720 cases of HL, 80,350 cases of NHL).

Prevalence


  • In 2025, there are an estimated 1,069,356 people living with, or in remission from lymphoma is the US.

  • There are 233,860 people living with Hodgkin Lymphoma

  • There are 835,496 people living with Non-Hodgkin Lymphoma

Survival

  • The 5-year relative survival rate for people with HL has risen to 89.0% for all races from 2015 to 2021. The 5-year survival rate is 94.4% for people with Hodgkin lymphoma (HL) who were under the age of 45 at diagnosis.

  • HL is now considered to be one of the most curable forms of cancer.

  • The 5-year relative survival rate for people with NHL has risen to 74.2% for all races from 2015 to 2021.

Deaths

  • In 2025, an estimated 20,540 members of the US population are expected to die from Lymphoma (19,390 NHL and 1,150 HL).

Outlook for the Future

  • We have 100% confidence that Lymphoma can be beaten!

Additional Resources

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  • External link opens in new tab or windowhttp://www.lls.org/lymphoma

  • External link opens in new tab or windowhttps://www.cancer.org/cancer/lymphoma.html

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  • External link opens in new tab or windowhttp://www.mayoclinic.org/diseases-conditions/lymphoma/home/ovc-20322779

  • External link opens in new tab or windowhttps://media.cancercare.org/publications/original/25-ccc_survivor.pdf?1302556249

“For I know the plans I have for you,” declares the Lord, “plans to prosper you and not to harm you, plans to give you hope and a future.” – Jeremiah 29:11

 

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